PHARMACEUTICAL COMPOSITION FOR ELEVATING RADIO-SENSITIVITY OF CANCER CELLS, PHARMACEUTICAL COMPOSITION FOR DETECTING CANCER CELLS WITH RADIO-SENSITIVITY, AND DETECTION METHOD THEREOF
CHEN, HAI WEN,陈海雯,陳海雯,SHIEH, DAR BIN,谢达斌,謝達斌,CHEN, CHIA CHUN,陈家俊,陳家俊,WU, PING CHING,吴炳庆,吳炳慶
申请号：
TW101134664
公开号：
TW201313238A
申请日:
2012.09.21
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical composition for elevating radio-sensitivity of cancer cells, which comprises: a nanopartical containing with a first element, which is iron, copper, or the combination thereof and a pharmaceutically acceptable carrier, wherein the nanopartical is a metal nanopartical, an alloy nanopartical, or a metal nanopartical with core-shell structure, and the size of the nanopartical is under a controllable range of 3 nm to 150 nm. In addition, the present invention provides a detection method to detect radio-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radio-sensitivity of the cancer cells through preferential uptake of the nanopartical, in order to enhance the radio-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.本發明係關於一種檢測癌細胞是否具有放射抗性之醫藥組成物,包括:一含第一元素之奈米粒子,其中,第一元素係為銅、鉑、或其組合;以及一醫藥可接受之載體。本發明之奈米粒子可為金屬奈米粒子、合金奈米粒子、或具核殼(core-shell)結構金屬之奈米粒子,且本發明能利用該奈米粒子之磁振顯影特性或電腦斷層顯影特性以檢測癌細胞是否具有放射抗性。此外,本發明另提供一種提升癌細胞放射敏感性的醫藥組成物,透過具放射線抗性的癌細胞會有增幅吸收奈米粒子之特性,以提升癌細胞之放射敏感性,增加癌細胞之放射治療功效。
