ANTHONY B. WOOD,GREGORY J. ARCHAMBEAU,RICHARD L. WATSON
申请号：
MX2010011846
公开号：
MX337862B
申请日:
2009.04.27
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating inflammatory neurodegenerative condition or disease or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.La presente invención se refiere a fluidos alterados por electrocinética (fluidos electrocinéticos enriquecidos con gas) que comprenden una solución acuosa iónica de nanoestructuras que contienen oxígeno estabilizadas por carga en una cantidad suficiente para proporcionar la modulación de al menos un potencial de membrana celular y conductividad de la membrana celular, y las composiciones terapéuticas y los métodos para su uso en el tratamiento de afecciones o enfermedades inflamatorias neurodegenerativas o al menos un síntoma de éstas. Las composiciones terapéuticas y los fluidos alterados por electrocinética y los métodos incluyen los fluidos acuosos iónicos alterados por electrocinética opcionalmente en combinac
