The present disclosure provides NO-releasing guanidine-coxib anti-cancer agents, having the structure of Formula (I):wherein R1, R11, Z and L are as defined in the detailed description pharmaceutical compositions comprising at least one of the compounds of Formula (I) and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, acne, or a disease mediated by arginine deficiency using a compound of Formula (I).
