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No-releasing guanidine-coxib anti-cancer agents
专利权人:
发明人:
Eduardo J. Martinez,John J. Talley,Terri L. Boehm
申请号:
US13940907
公开号:
US09044464B2
申请日:
2013.07.12
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present disclosure provides NO-releasing guanidine-coxib anti-cancer agents, having the structure of Formula (I):wherein R1, R11, Z and L are as defined in the detailed description pharmaceutical compositions comprising at least one of the compounds of Formula (I) and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, acne, or a disease mediated by arginine deficiency using a compound of Formula (I).
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