LANDES, Gregory,CHEN, Francine,BEZABEH, Binyam,FOLTZ, Ian,TSE, Kam Fei,JEFFERS, Michael,STARLING, Gary,MEZES, Peter,KHRAMTSOV, Nikolia,MESRI, Mehdi
申请号：
ES04757910
公开号：
ES2557769T3
申请日:
2004.03.19
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
An isolated human antibody or a binding fragment thereof that specifically binds to T cells, immunoglobulin domain and mucin domain 1 (TIM-1), wherein said antibody or binding fragment has a heavy chain polypeptide comprising a amino acid sequence comprising three complementarity determining regions (CDRs) and a light chain polypeptide comprising three CDRs, wherein the three CDRs heavy chains and the three CDRS light chains are selected from: (a) a heavy chain CDR1 which comprises an amino acid sequence GFIFSRYGMH, a heavy chain CDR2 comprising the amino acid sequence VIWYDGSNKLYADSVK, a heavy chain CDR3 chain comprising the amino acid sequence DYYDNSRHHWGFDY, a light CDR1 chain comprising the amino acid sequence RSSRSLLDSDDGNTYLD, a CDR1 chain light chain comprising the amino acid sequence TLSYRAS, and a light CDR3 chain that bought hence the amino acid sequence MQRVEFPIT； and (b) a heavy CDR1 chain comprising the amino acid sequence GGSISSDGYYWS, a heavy CDR2 chain comprising the amino acid sequence YIYYSGSTFYNPSLKS, a heavy CDR3 chain comprising the amino acid sequence ESPHSSNWYSGFDC, a light CDR1 chain comprising the amino acid sequence RASQSIGSRLH, a light CDR2 chain comprising the YASQSFS amino acid sequence, and a light CDR3 chain comprising the HQSSNLPFT amino acid sequence.Un anticuerpo humano aislado o un fragmento de enlazamiento del mismo que se enlaza específicamente a células T, dominio de inmunoglobulina y dominio 1 de mucina (TIM-1), en donde dicho anticuerpo o fragmento de enlazamiento tiene un polipéptido de cadena pesada que comprende una secuencia de aminoácidos que comprende tres regiones determinantes de complementariedad (CDRs) y un polipéptido de cadena liviana que comprende tres CDRs, en donde las tres cadenas pesadas CDRs y las tres cadena liviana CDRS se seleccionan de: (a) un CDR1 de cadena pesada que comprende una secuencia de aminoácidos GFIFSRYGMH, un CDR2 de cadena pesada que comprende la secuencia de aminoácidos VIWYDGSNKLYADSVK, un
