ПРОИЗВОДНЫЕ ХИНОЛИНА И СОДЕРЖАЩИЕ ИХ ИНГИБИТОРЫ MELK

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专利权人:

ОНКОТЕРАПИ САЙЕНС; ИНК. (US)

发明人:

МАЦУО Е (JP),ХИСАДА Содзи (JP),НАКАМУРА Юсуке (JP),АХМЕД Ферьян (US),ХАНТЛИ Рэймонд (US),УОКЕР Джоэл Р. (US),ДЕКОРНЕ Элен (US)

申请号：

RU2013108865/04

公开号：

RU2013108865A

申请日:

2011.07.28

申请国别(地区):

RU

年份:

2014

代理人:

摘要：

1. A compound represented by the following formula, or a pharmaceutically acceptable salt thereof: gdeRpredstavlyaet soboyatom hydrogen, halogen, cyano, optionally substituted C-Ctsikloalkil optionally substituted aromatic heterocyclic group, optionally substituted C-alkylsulfinyl, optionally substituted alkylsulfonyl C-or-CO-R [gdeRpredstavlyaet soboyneobyazatelno substituted C-alkyl optionally substituted aliphatic geterotsiklicheskiy- (C-Calkilenil) optionally substituted C-Ctsikloalkil optionally substituted aryl, neo byazatelno substituted aromatic heterocyclic group, hydroxy, optionally substituted C-alkoxy or-NRR (wherein R Ryavlyayutsya identical or different and represent hydrogen soboyatom optionally substituted aryl, optionally substituted C-alkyl optionally substituted with C-Ctsikloalkil optionally substituted aromatic geterotsiklicheskiy- (C -Calkilenil) ilineobyazatelno substituted aliphatic geterotsiklicheskiy- (C-Calkilenil))], R soboyatom hydrogen, halogen, hydroxy, di (C-Ci ^ alkyl) amino (C-Calkileniloksi) oPTIONAL a substituted aryl, an optionally substituted aromatic heterocyclic group, an optionally substituted aliphatic heterocyclic group, -NRR [wherein R Ryavlyayutsya identical or different and represent hydrogen soboyatom optionally substituted C-Ci ^ alkyl, C-Caminoalkil optionally substituted C-Calkilamino- (C-Calkilenil) optionally substituted di (C-Ci ^ alkyl) amino (C-Calkilenil) optionally substituted C-Calkanoilamino- (C-Calkilenil) or- (CH) -R (where n is an integer from 0 to 6, iRpredstavlyaet soboyneobyazatelno substituted C- Ctsikloalkil not

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