The present invention is concerned with pharmaceutical containers for drug delivery having a barrel configured to slidably receive a stopper. For eluting the contents of the container through an outlet, the stopper must slide within the container. For smooth action adequate break loose and glide forces have to be achieved. The inventive containers achieve these forces by a certain ratio of angels of the most proximal and most distal annular protrusions of the stopper, a certain maximum break loose force to glide force ratio and a certain total glide force variation value.