PROBLEM TO BE SOLVED: To reduce the burden on patients suffering from chronic pain by avoiding the side effects of narcotic opioid drugs, which have been conventionally used for severe chronic pain such as cancer pain.SOLUTION: The present invention provides a novel non-narcotic analgesic having the similar powerful analgesic effect as narcotic analgesics which have been conventionally used to reduce or treat severe chronic pain such as cancer pain, by combining a Cox inhibitor (e.g., S-flurbiprofen) with a morphinan narcotic antagonist (e.g., butorphanol tartrate), as well as a method for reducing or treating pain.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】 従来がん性疼痛等の激しい慢性痛に用いられてきた麻薬性のオピオイド薬物による副作用の問題を回避し、慢性疼痛に苦しむ患者の負担を軽減するために有用である。【解決手段】 本発明は、Cox阻害薬(例えば、S-フルルビプロフェン)とモルフィナン系麻薬拮抗鎮痛薬(例えば、酒石酸ブトルファノール)との組み合わせによる、がん性疼痛等の激しい慢性痛の軽減又は処置に従来使用されてきた麻薬性鎮痛薬と同程度の強力な鎮痛作用を有する新たな非麻薬性鎮痛薬並びに疼痛の軽減又は処置方法を提供する。【選択図】なし