ANALOGUES DE L'INDOMÉTACINE DESTINÉS AU TRAITEMENT DU CANCER DE LA PROSTATE RÉSISTANT À LA CASTRATION

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;VANDERBILT UNIVERSITY

发明人:

MARNETT, LAWRENCE, J.,LIEDTKE, ANDY, J.,PENNING, TREVOR, M.,ADENIJI, ADEGOKE, O.,BYRNS, MICHAEL, C.

申请号：

EP12842553

公开号：

EP2768499A4

申请日:

2012.10.17

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.

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http://www.ckcest.cn/home/