KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL;경북대학교 산학협력단;KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;경북대학교병원
发明人:
SUK, Kyoung Ho,석경호,SONG, Gyun Jee,송견지
申请号：
KRKR2016/012746
公开号：
WO2017/078499A2
申请日:
2016.11.07
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a pharmaceutical composition for the prevention or treatment of a neuroinflammatory disease, the composition containing a protein tyrosine phosphatase inhibitor. The protein tyrosine phosphatase inhibitor of the present invention inhibits activated microglia cells by decreasing the level of nitric oxide (NO) in microglia cells and reducing the expression of proinflammatory factors TNFα, IL1β, iNOS, and the like, and thus, can be favorably used in the prevention or treatment of a neuroinflammatory disease.La présente invention concerne une composition pharmaceutique pour la prévention ou le traitement d'une maladie neuroinflammatoire, ladite composition contenant un inhibiteur de la protéine tyrosine phosphatase. L'inhibiteur de la protéine tyrosine phosphatase de la présente invention inhibe les cellules microgliales activées en diminuant le taux d'oxyde nitrique (NO) dans les cellules microgliales et en réduisant l'expression de facteurs pro-inflammatoires TNFα, IL1ß, iNOS, et analogues, et peut ainsi être utilisée avantageusement dans la prévention ou le traitement d'une maladie neuroinflammatoire.본 발명은 단백질 타이로신 탈인산화효소(protein tyrosine phosphatas) 억제제를 포함하는 신경염증성 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명의 단백질 타이로신 탈인산화효소 억제제는 소교세포에서 산화질소(NO) 수준의 감소, 전염증성 인자인 TNFα, IL1β, iNOS 등의 발현의 감소를 통하여 활성화된 소교세포를 저해함으로써 신경염증성 질환의 예방 또는 치료에 유용하게 사용될 수 있다.
