POLYMORPHE STABLE DE CHLORHYDRATE DE N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE, ET METHODES DE PRODUCTION ET UTILISATIONS PHARMACEUTIQUES DUDIT POLYMORPHE
CONNELL, RICHARD D.,MOYER, JAMES D.,MORIN, MICHAEL J.,KAJIJI, SHAMA M.,FOSTER, BARBARA A.,FERRANTE, KAREN J.,NORRIS, TIMOTHY,RAGGON, JEFFREY W.,SILBERMAN, SANDRA L.
申请号：
CA2632556
公开号：
CA2632556C
申请日:
2000.11.09
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to a stable crystalline form of N-(3- ethynylphenyl)-6,7--bis (2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the A polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph A form of N-(3--ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride, as well as other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
