CONGREVE, MILES STUART,ANDREWS, STEPHEN PHILIPPE,MASON, JONATHAN STEPHEN,RICHARDSON, CHRISTINE MARY,BROWN, GILES ALBERT
申请号：
MX2012009073
公开号：
MX2012009073A
申请日:
2011.02.07
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
According to the invention there is provided a compound of formula A1 which may be useful in the treatment of a condition or disorder ameliorated by the inhibition of the A1- A2b or, particularly, the A2a receptor wherein the compound of formula A1 has the structure, wherein, A represents Cy1 or HetA Cy1 represents a 5- to 14-membered aromatic, fully saturated or partially unsaturated carbocyclic ring system comprising one, two or three rings, which Cy1 group is optionally substituted by one or more R4a substituents HetA represents a 5- to 14-membered heterocyclic group that may be aromatic, fully saturated or partially unsaturated, and which contains one or more heteroatoms selected from O, S and N, which heterocyclic group may comprise one, two or three rings and which HetA group is optionally substituted by one or more R4b substituents B represents a Cy2 or HetB Cy2 represents a 3- to 10-membered aromatic, fully saturated or partially unsaturated carbocyclic ring system comprising one or two rings, which Cy2 group is optionally substituted by one or more R4c substituents HetB represents a 3- to 10-membered heterocyclic group that may be aromatic, fully saturated or partially unsaturated, and which contains one or more heteroatoms selected from O, S and N, which heterocyclic group may comprise one or two rings and which HetB group is optionally substituted by one or more R4d substituents.De acuerdo con la invención se proporciona un compuesto de fórmula A1 que puede ser útil en el tratamiento de una afección o trastorno mejorada por la inhibición del receptor de A1- A2b o, en particular, del receptor de A2a en donde el compuesto de fórmula A1 tiene la estructura (ver fórmula) en donde A representa Cy1 o HetA Cy1 representa un sistema de anillo carbocíclico de 5 a 14 miembros aromático, completamente saturado o parcialmente insaturado que comprende uno, dos o tres anillos, cuyo grupo Cy1 es opcionalmente sustituido por uno o más sustituyentes R4a HetA representa un
