Peter Johnson;Mark Cragg;Ali Roghanian;Stephen Beers;Ingrid Teige;Sean Lim;Bjorn Frendeus;Martin Glennie
发明人:
Mark Cragg,Martin Glennie,Ali Roghanian,Stephen Beers,Peter Johnson,Sean Lim,Bjorn Frendeus,Ingrid Teige
申请号：
US13817744
公开号：
US20130251706A1
申请日:
2011.08.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides a method of treating a patient having target cells that express FcyRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcyRIIb； in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcyRIIb； characterized in that the patient is selected on the basis that their target cells express an elevated level of FcyRIIb.
