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結晶の表面自由エネルギーを指標として評価される結晶及び該結晶を含有してなる医薬組成物
专利权人:
株式会社ポーラファルマ;日本農薬株式会社
发明人:
増田 孝明,金田 秀男
申请号:
JP20140163640
公开号:
JP6268060(B2)
申请日:
2014.08.11
申请国别(地区):
日本
年份:
2018
代理人:
摘要:
PROBLEM TO BE SOLVED: To prevent generation of luliconazole an isomer due to influences of moisture, light, and the like, and to provide means to improve stability thereof.SOLUTION: Provided is a luliconazole crystal obtained by recrystallization using a solvent selected from a mixed solvent of ethyl acetate-n-hexane or a mixed solvent of ethanol-water. The crystal of luliconazole is produced by a production method comprising steps of: evaluating the crystal as a crystal having a low proportion of Z isomer and being suitable for a pharmaceutical formulation using as an index that a surface free energy of a luliconazole crystal is 28 mJ/mor less and a proportion of a polar component in the surface free energy is 35% or less; and selecting the crystal evaluated in the above step as a crystal having a low proportion of Z isomer and being suitable for a pharmaceutical formulation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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