Sarvajit CHAKRAVARTY,Dhananjay PENDHARKAR,Sreekanth A. RAMACHANDRAN,Chandramohan BATHULA,Sanjeev SONI,Vivek KUMAR,Uzma SAEED,Abhinandan Kumar DANODIA,Ankesh SHARMA,Pradeep S. JADHAVAR
申请号：
US16729696
公开号：
US20200206233A1
申请日:
2019.12.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.
