CHANGJIANG, HUANG,HUI, YE,XUEJING, YAO,HAOHUA, JIE,SHIZHONG, ZHAI,JIANMIN, FANG,SHIZHONG, HAI
申请号：
CA3062265
公开号：
CA3062265A1
申请日:
2019.05.20
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present disclosure relates to a process for preparing an intermediate ofantibody-drugconjugate. Compared with the conventional art, the process for preparing anintermediate of theantibody-drug conjugate provided by the present disclosure significantlyreduces the feed loss fordrug moiety, such as MMAD/MMAE or MMAF, etc., as drug moiety is involved inthe last stepof the reaction, thereby effectively reducing production costs, as well asincreasing productionefficiency. In addition, the process provided by the present disclosure issimple, environmentallyfriendly and suitable for large-scale industrialization.
