A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine 1 mM to 5 mM calcium salt 100 mM to 300 mM NaCl and a buffering agent for maintaining a pH of approximately between 6 and 8. Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine 1 mM to 5 mM calcium salt 100 mM to 300 mM NaCl and a buffering agent for maintaining a pH of approximately between 6 and 8. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine 1 mM to 5 mM calcium salt and a buffering agent.
