A resettable drug delivery device (1) is provided comprising a body (9, 11), a cartridge holder (7) for receiving a cartridge (8), and means (13, 14, 17, 18) for releasably coupling the cartridge holder (7) to the body (9, 11) or the dose setting mechanism. During an initial rotational coupling movement of the cartridge holder (7) relative to the body (9, 11) or the dose setting mechanism the cartridge holder (7) is caused to move in a first axial direction relative to the body (9, 11) or the dose setting mechanism and during a continued rotational coupling movement of the cartridge holder (7) relative to the body (9, 11) or the dose setting mechanism the cartridge holder (7) is caused to move in a second, contrary axial direction.
