MEISSNER, TORSTEN B.,MULUMBA, KABUNGO Y.,FERREIRA, LEONARDO M. R.,COWAN, CHAD A.
申请号：
CA2984237
公开号：
CA2984237A1
申请日:
2016.03.28
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Disclosed herein are modified primary human T cells and populations thereof comprising a genome in which the CTLA4, PD1, TCRA, TCRB, and/or B2M genes have been edited to generate an off-the-shelf universal CAR T cell from allogeneic healthy donors that can be administered to any patient while reducing or eliminating the risk of immune rejection or graft versus host disease, and which are not prone to T cell inhibition, and methods for allogeneic administration of such cells to reduce the likelihood that the cells will trigger a host immune response when the cells are administered to a subject in need of such cells.
