Provided are chimeric antigen receptors (CARs), which contain antibody portions specific to G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D) and polynucleotides that encode CARs specific for GPRC5D. The disclosure further relates to genetically engineered cells, containing such GPRC5D-binding receptors, and uses thereof in adoptive cell therapy.本發明提供含有G蛋白偶合受體C類第5群成員D(GPRC5D)特異性抗體部分之嵌合抗原受體(CAR),及編碼GPRC5D特異性CAR之聚核苷酸。本發明進一步係關於含有此類GPRC5D結合受體的經基因工程改造之細胞,及其在過繼細胞療法中之用途。