GORE VINAYAK GOVIND,MANOJKUMAR BINDU,SHINDE DATTATRAYA,KOKANE DATTATREY
申请号：
NZ59792010
公开号：
NZ597920A
申请日:
2010.08.06
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
The present disclosure relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions. The disclosure further provides a process for the preparation of anhydrous tiotropium bromide, comprising the steps of: providing a solution of scopine di-(2-thienyl)glycolate and a ketone as the first organic solvent； adding a solution of methyl bromide in a second organic solvent to the mixture from step (a) or vice versa； isolating anhydrous tiotropium bromide from the mixture obtained in step (b)； and drying the isolated anhydrous tiotropium bromide. The anhydrous tiotropium bromide may be used in the treatment of a respiratory disorder, such as asthma or COPD, wherein the COPD includes chronic bronchitis and emphysema, and my be administered from a dry powder inhaler (DPI), an aqueous nebulizer or a pressurized metered dosage inhaler (pMDI).
