Substituted reverse pyrimidine bmi-1 inhibitors

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专利权人:

PTC THERAPEUTICS INC.

发明人:

Du, Wu,Wilde, Richard,Lee, Chang-Sun,Baiazitov, Ramil,Cao, Liangxian,Davis, Thomas,Liu, Ronggang,Moon, Young-Choon,Paget, Steven,Ren, Hongyu,Sydorenko, Nadiya

申请号：

NZ70890913

公开号：

NZ708909A

申请日:

2013.11.21

申请国别(地区):

NZ

年份:

2019

代理人:

摘要：

Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. 4,6-diamino-pyrimidine compounds of Formula (I) are described, wherein R1 is substituted 1H-benzimidazolyl, X is N, R2 is amino and the remaining substituents are as defined herein.

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中国工程科技知识中心

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