The present invention relates to systems, methods and apparatus for improving the yield for separating components of fluids, for example biological or sensitive fluids such as blood, and improving the component yield, for example, from donated whole blood by separating its components by density in a centrifuge bowl with a multi-axial lumen. The apparatus, system, and method eliminate the need to batch-type separate blood and can reduce the time needed to treat patients suffering from T-cell or white blood cell mediated diseases or conditions to less than 70 minutes. In one aspect, the invention is a centrifuge bowl ( 10 ) comprising an outer housing ( 100 ) a core ( 200 ) a lower plate ( 300 ) a lumen ( 400 ) a first bowl channel ( 420 ) within said lumen ( 400 ) for inflowing said fluid ( 800 ) a second bowl channel ( 410 ) for removing a first separated fluid component ( 810 ) and a third bowl channel ( 740 ) for removing a second separated fluid component ( 820 ).
