To provide pharmaceutical preparation exhibiting satisfactory dissolution property in a wide pH range. The pharmaceutical composition is characterized by containing (A) N 1 -(5-chloropyridin-2-yl)-N 2 -((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide, represented by the following formula (1), a pharmacologically acceptable salt thereof, or a hydrate of any of these, and (B) one or more species selected from the group consisting of a sugar alcohol and a water-swelling additive.本發明提供一種在廣泛的pH範圍內顯示良好溶出性之製劑。本發明係關於一種醫藥組合物，其特徵在於含有：(A)以下述式(1)所表示之N1-(5-氯吡啶-2-基)-N2-((1S,2R,4S)-4-[(二甲基胺基)羰基]-2-{[(5-甲基-4,5,6,7-四氫噻唑[5,4-c]吡啶-2-基)羰基]胺基}環己基)乙二醯胺、其藥理學上容許之鹽、或其等之水合物；與(B)選自糖醇類及水膨潤性添加劑中之1種或2種以上。
