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NEW COMBINATION AND APPLICATION
专利权人:
ХЕЛПЕРБИ ТЕРАПЬЮТИКС ЛИМИТЕД (GB)
发明人:
ХУ Яньминь (GB),КОУТС Энтони М. Р. (GB)
申请号:
RU2012146093/15
公开号:
RU2012146093A
申请日:
2011.03.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. The use of an anesthetic agent for the destruction of clinically latent microorganisms associated with microbial infection. 2. The use according to claim 1, wherein the anesthetic agent is a local anesthetic. The use according to claim 2, in which the local anesthetic is selected from benzocaine, chlorprocaine, cocaine, cyclomethicaine, dimethocaine, propoxicaine, procaine, proparacaine, tetracaine, articaine, bupivacaine, cinchocaine, ethidocaine, levobupivacaine, lepocaine, pripocaine, pepacin, pripocaine, trimecaine and their combinations. 4. The use of claim 2, wherein the local anesthetic is diclonin or a pharmaceutically acceptable derivative thereof, preferably diclonin hydrochloride. The use according to one of the preceding claims, wherein the anesthetic agent is used in combination with an antimicrobial agent. 6. The use of claim 5, wherein the antimicrobial agent is mupirocin or a pharmaceutically acceptable derivative thereof. The use of claim 5, wherein the antimicrobial agent is capable of killing clinically latent microorganisms. The use according to claim 7, wherein the antimicrobial agent is selected from the group consisting of: 6,8-dimethoxy-4-methyl-1- (3-phenoxyphenyl) -2,3-dihydro-1H-pyrrolo [3,2-c ] quinoline; 6,8-dimethoxy-4-methyl-1- (2-phenoxyphenyl) -2,3-dihydro-1H-pyrrolo [3,2-c] quinoline; 1-cyclopropyl-6,8-dimethoxy-4 Methyl-2,3-dihydro-1H-pyrrolo [3,2-c] quinoline; 8-methoxy-4-methyl-1- (4-phenoxyphenyl) -2,3-dihydro-1H-pyrrolo [3,2 -c] quinoline; {2- [4- (8-methoxy-4-methyl-2,3-dihydro-1H-pyrrolo [3,2-c] quinolin-1-yl) phenyloxy] ethyl} dimethylamine; 8- methoxy-4-methyl-1- [4- (pyridin-3-yloxy) phenyl] -2,3-dihydro-1H-pyrrolo [3,2-c] quinoline; 4-methyl-8-phenoxy-1-phenyl -2,3-dihydr -1H-pyrrolo [3,2-c] quino1. Применение анестетического агента для уничтожения клинически латентных микроорганизмов, ассоциированных с микробной инфекцией.2. Применение по п.1, в котором анестетический агент является местным анестетиком.3. Применение п
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