The present invention involves administering an effective amount of a dihydropyrazino-pyrazine compound to a patient having a polymorphic glioblastoma (GBM) characterized by O 6 -methylguanine-DNA methyltransferase (MGMT) expression and / or promoter methylation status (GBM) characterized by O 6 -methylguanine-DNA methyltransferase (MGMT) expression and / or promoter methylation status, which comprises administering to a subject a therapeutically effective amount of a polymorphic glioblastoma (GBM).본원은 O6-메틸구아닌-DNA 메틸트랜스퍼라제(MGMT) 발현 및/또는 촉진자 메틸화 상태로 특징지어지는 다형성아교모세포종(GBM)을 갖는 환자에게 유효량의 디하이드로피라지노-피라진 화합물을 투여함을 포함하는, O6-메틸구아닌-DNA 메틸트랜스퍼라제(MGMT) 발현 및/또는 촉진자 메틸화 상태로 특징지어지는 다형성아교모세포종(GBM)을 치료 또는 예방하는 방법을 제공한다.
