Filling and closing device (20) for an active principle applicator (1), where the active principle applicator (1) has a lower part (2) and a cover (3) between which a receiving space (4) is formed ) for the preparation of the active ingredient, the lower part (2) and the cover (3) each having a peripheral sealing edge (5, 6) for the tight connection of the cover (3) with the lower part (2) , where the lower part (2) is provided with an applicator tube (7) that flows into the receiving space (4) through an internal mouth (8), where the sealing edge (5) of the lower part (2) forms a circumvalent bearing surface (9) on its lower side away from the cover (3), where the applicator tube (7) overlaps the sealing edge (5), at least partially, in relation to its plane, so that the Support surface (9) has a segment of support surface (10) covered at least in part by the applicator tube (7), where the filling and closing device (20 ) has a receiving element (21) for the lower part (2) of the active principle applicator (1), with a circumvalent pressure surface (22) for the support of the support surface (9) of the lower part (2) ), and with a housing channel (23), which extends to below the pressure surface (22) and is provided for the applicator tube (7) of the lower part (2), where the receiving element (21 ) is structured in at least two parts, with a base element (24) and a cover element (25), movable in front of the base element (24), where the housing channel (23) is formed between the base element (24 ) and the cover element (25), where the circumvalent pressure surface (22) extends above the base element (24) and the cover element (25) so that a segment of the pressure surface ( 26) on the upper side of the cover element (25) opposite the housing channel (23), so that the covered segment of the s is supported a supporting surface (10) of the active ingredient applicator (1).Dispositivo de llenado y cierre (20) para un aplicador de principios activos (1), donde el aplic