anti-vla-1 antibody, composition comprising it, nucleic acid and vector as well as in vitro methods for determining the level of vla-1 in tissue and for identifying integrin domain i inhibitor
BIOGEN IDEC MA INC.;BIOGEN MA INC.;Biogen Idec MA, Inc.;Biogen, INC.
发明人:
Ellen A. Garber,Jose W. Saldanha,Michael Karpusas,Paul D. Lyne
申请号：
BR0209792
公开号：
BRPI0209792B1
申请日:
2002.04.12
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
"antibodies to vla-1". The present invention relates to antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immune disorders in an individual. Also included are complex crystal structures formed by vla-1 antibodies and their ligands, and vla-1 antagonists and agonists identified using the structure coordinates of these structures."anticorpos para vla-1 ". a presente invenção refere-se a anticorpos que especificamente ligam-se à integrina de vla-1 e métodos de usar estes anticorpos para tratar distúrbios imunológicos em um indivíduo. também incluídas são estruturas cristalinas de complexos formados por anticorpos de vla-1 e seus ligandos, e antagonistas e agonistas vla-1 identificados usando as coordenadas da estrutura destas estruturas.
