Compound of formula (I), (I) values of R, R1, R2, R3, R4, X1, X2, X3, X4, Z, Cy substitutes and n, m, p variables are provided in the claims or pharmaceutically acceptable salt, and pharmaceutical composition on a basis thereof, and their usage at disorders treatment related to P13K enzyme mechanisms, such as respiratory diseases, viral and nonviral infections, etc. Table: 9