包含GLP-1/胰高血糖素雙重激動劑、連接子和透明質酸的接合物农业专利-农业专业知识服务系统

发明人:: KADEREIT, DIETER,卡德莱特　迪特,卡德萊特　迪特,WAGNER, MICHAEL,瓦格纳　麦克,瓦格納　麥克,OLPP, THOMAS,欧普　汤玛士,歐普　湯瑪士,MEYER, NINO,梅耶　尼诺,梅耶　尼諾,BOSSART, MARTIN,波沙特　马汀,波沙特　馬汀,EVERS, ANDREAS,埃弗斯　安德烈斯,SAKHAII, PEYMAN,莎哈尹　佩曼,卡德莱特迪特,卡德萊特迪特,瓦格纳麦克,瓦格納麥克,欧普汤玛士,歐普湯瑪士,梅耶尼诺,梅耶尼諾,波沙特马汀,波沙特馬汀,埃弗斯安德烈斯,莎哈尹佩曼

摘要：: The present invention relates to a conjugate or a pharmaceutically acceptable salt thereof comprising an GLP-1/Glucagon receptor agonist, a linker anda hyaluronic acid hydrogel bearing -L1-L2-L-Y-R20 groups, wherein Y represents an GLP-1/Glucagon receptor agonist moiety； and -L is a linker moiety-by formula (Ia), wherein the dashed line indicates the attachment to one of the amino groups of the GLP-1/Glucagon receptor agonist moiety by forming an amide bond. The invention further relates to pharmaceutical compositions comprising said conjugates as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by GLP-1/Glucagon receptor agonist.本發明涉及一種接合物或其藥學上可接受的鹽，所述接合物包含GLP-1/胰高血糖素受體激動劑、連接子和具有-L1-L2-L-Y-R20基團的透明質酸水凝膠，其中，Y表示GLP-1/胰高血糖素受體激動劑部分；並且-L是式(Ia)的連接子部分，其中，虛線表示藉由形成醯胺鍵與GLP-1/胰高血糖素受體激動劑部分的胺基中的一個連接。本發明進一步涉及包含所述接合物的醫藥組合物，及其作為用於治療或預防可藉由GLP-1/胰高血糖素受體激動劑治療的疾病或病症的藥物的用途。