Sudhir Agrawal,Ekambar Kandimalla,Mallikarjuna Putta,Ireneusz Nowak,Nicola LaMonica,Weiwen Jiang,Michael Reardon,Tao Lan
申请号：
US13072017
公开号：
US08877722B2
申请日:
2011.03.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The inventors have examined the means for providing more efficacious miRNA blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy of miRNA blocking molecules. These features include the presence of multiple 3′ ends and a linker at the 5′ ends. Surprisingly, these features improve the efficacy of the gene expression blocking compounds in a manner that decreases the compounds biologic instability. Even more surprisingly, this effect has been found to be applicable to both DNA and RNA oligonucleotide-based compounds and to have application in traditional antisense and RNAi technology.
