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Methods and compositions for the administration of 3-halopyruvate and related compounds for the treatment of cancer
专利权人:
THE JOHNS HOPKINS UNIVERSITY;UNIV JOHNS HOPKINS
发明人:
GESCHWIND, JEAN-FRANCOIS,VALI, MUSTAFA,GESCHWIND JEAN-FRANCOIS,VALI MUSTAFA
申请号:
ES09808532
公开号:
ES2464729T3
申请日:
2009.08.21
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A pharmaceutical composition comprising a pharmaceutical agent represented by the general formula: ** Formula ** in which, independently each time: X represents a halide, a sulfonate, a carboxylate, an alkoxide or an amine oxide; R1 represents OR, H, N (R ") 2, C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl or C6-C12 heteroaryl; R" represents H, C1-C6 alkyl or C6-C12 aryl; R represents H, an alkali metal, C1-C6 alkyl, C6-C12 aryl or C (O) R '; and R 'represents H, C1-C20 alkyl or C6-C12 aryl; and wherein the pharmaceutical composition has an acidity greater than or equal to approximately pH 2 and less than or equal to pH 6.Una composición farmacéutica que comprende un agente farmacéutico representado por la fórmula general:**Fórmula** en la que, independientemente cada vez: X representa un haluro, un sulfonato, un carboxilato, un alcóxido o un óxido de amina; R1 representa OR, H, N(R")2, alquilo C1-C6, arilo C6-C12, heteroalquilo C1-C6 o heteroarilo C6-C12; R" representa H, alquilo C1-C6 o arilo C6-C12; R representa H, un metal alcalino, alquilo C1-C6, arilo C6-C12 o C(O)R'; y R' representa H, alquilo C1-C20 o arilo C6-C12; y en donde la composición farmacéutica tiene una acidez superior o igual a aproximadamente pH 2 e inferior o igual a pH 6.
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