CHARRIER, Jean-damien,DURRANT, Steven,KAY, David,O'DONNELL, Michael,KNEGTEI, Ronald,MACCORMICK, Somhairle,PINDER, Joanne,VIRANI, Anisa,YOUNG, Stephen,BINCH, Hayley,CLEVELAND, Thomas,FANNING, Lev, T.d.,ODONNELL, Michael
申请号：
AU2016203414
公开号：
AU2016203414A1
申请日:
2016.05.25
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016203414A120160623.pdf#####Abstract The present invention relates to pyrazine compounds, pharmaceutical compositions comprising them, and methods for inhibiting ATR protein kinase for treating various diseases, disorders, and conditions including cancer, HIV, hepatitis, adenovirus and psoriasis. Additionally the invention discloses processes for preparing the compounds, intermediates used in the preparation, and methods of using the compounds in in vitro applications including the study of kinases in biological and pathological phenomena, the study of intracellular signal transduction pathways mediated by such kinases, and the comparative evaluation of new kinase inhibitors.
