Novartis AG;Sloan-Kettering Institute for Cancer Research
发明人:
DANIEL DYLAN,JOYCE, Johanna,SUTTON JAMES
申请号:
PL12720761
公开号:
PL2704713T3
申请日:
2012.05.04
申请国别(地区):
PL
年份:
2017
代理人:
摘要:
The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.