[problem] provides controlled drug release excellent novel injection agent. [solution] for example, for intravitreal administration, have 1-30,The drug and (w/v) drug of 000 % (w/v) Trehalose and 01 ~ 3 containing 0.1 ~ 60 % (w/v),The combination of 000 %, phosphate buffer, body fluid (tear, glass etc.) Or deposit is formed when contacting with doubtful body fluid. [selection figure] is not necessarily to