The present invention relates to a method for producing a pharmaceutical delivery system, the use of a surface-reacted calcium carbonate for improving the friability of a pharmaceutical delivery system as well as for improving the flowability of a pharmaceutical delivery system and a pharmaceutical delivery system obtained by the method.本發明係關於一種用於製造醫藥傳遞系統之方法,表面反應碳酸鈣用於提高醫藥傳遞系統之脆度以及用於提高醫藥傳遞系統之流動性的用途,以及藉由該方法獲得之醫藥傳遞系統。