WIECZOREK BIRGIT,TAGMOSE TINA M¸LLER,SASS ˜RUM KRISTIAN,ANDERSEN BIRGITTE,OLSEN J¸RGEN
申请号：
IN201747021545
公开号：
IN201747021545A
申请日:
2017.06.20
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The invention relates to a derivative of a FGF21 protein having a cysteine residue at a position corresponding to position 167 169 170 171 172 173 174 175 and in particular position 180 or position 181 of mature human FGF21 and derivatives thereof having a side chain attached to this cysteine. The FGF21 derivatives of the invention display high potency towards the FGF receptors. The invention also relates to pharmaceutical compositions comprising such FGF21 derivatives and pharmaceutically acceptable excipients as well as the medical use of the FGF21 derivatives.
