Intensity standardization of MRI data sets aims at correcting scanner-dependent intensity variations. An automatic technique, called STI, which shares the simplicity and robustness of histogram-matching techniques, but also incorporates tissue spatial intensity information, has been discovered. The method comprises registering a medical image to a standard image applying one or more masks to the medical and standard images for isolating certain specific image components determining the most common intensity data pair between the medical and standard images for each isolated image component calculating a formula that joins the most common intensity data pair of each image component and interpolating an intensity data adjustment using the formula and applying it to the medical image data to generate a standardized version of the medical image.
