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Method for production of orally rapidly disintegrating tablet comprising imidafenacin as active ingredient
专利权人:
Toshihiro Ishizaki;Yoshinobu Aoki
发明人:
Toshihiro Ishizaki,Yoshinobu Aoki
申请号:
US12865632
公开号:
US08722133B2
申请日:
2009.01.30
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention herein provides an imidafenacin-containing orally rapidly disintegrating tablet which is excellent in the photostability.The present invention comprises the steps of: (A) granulating imidafenacin together with starch to thus give a granulated product having an imidafenacin concentration ranging from 0.001 to 3% by mass and a starch concentration ranging from 40 to 99.999% by mass; (B) covering the granulated product prepared in the step (A) with a non-cellulosic coating agent; and (C) blending the granulated product obtained in the preceding step (B) with an excipient and a disintegrating agent and then forming the resulting mixture into a tablet according to the compression molding technique.
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