DINAH W. Y. SAH,R. BLAKE PEPINSKY,PAULA ANN BORJACK-SJODIN,STEPHAN S. MILLER,ANTHONY ROSSOMANDO
申请号：
IS6879
公开号：
IS2867B
申请日:
2003.07.17
申请国别(地区):
IS
年份:
2014
代理人:
摘要：
A variant neublastin polypeptide suitable for formulation of a conjugate comprising the variant neublastin polypeptide coupled to a polymer containing a polymer containing a polyalkylene glycol moiety is disclosed. The present conjugate has prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to non-modified or wild-type forms of neublastin. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
