Mountain View Pharmaceuticals, Inc.;Duke University
发明人:
WILLIAMS, L., David,Hershfield, Michael S.,KELLY, Susan, J.,SAIFER, Mark, G., P.,SHERMAN, Merry, R.
申请号：
DK10180672
公开号：
DK2316475T3
申请日:
1999.08.02
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. <；IMAGE>；
