The present invention provides a glycosylation atrial natriuretic peptide with extended sustaining properties in blood, and that has cGMP increasing activity. The present invention provides a modified peptide coupled to at least one saccharide directly by a glycoside bond, or coupled to at least one hANP peptide through a linker structure, and also provides a pharmaceutically permissible salt thereof, and a drug or the like containing the modified peptide or salt thereof as an active ingredient.本發明係提供血中持續性被延長，且保持cGMP上升活性的修飾心房利尿鈉肽。本發明係提供一種修飾胜肽或其藥學上可容許的鹽、含有該修飾胜肽或其鹽作為有效成分的醫藥等；該修飾胜肽係至少一個之糖物質直接藉由醣苷鍵連結、或藉由連結構造(linker structure)，與至少一個之hANP胜肽連結的修飾胜肽。
