Methods, systems and computer-readable code for generating a forecast of a life-threatening condition, for example sepsis, in a subject, for example an infant, are disclosed. According to some embodiments, the forecast is generated in accordance with measurement values for a plurality of different vital sign parameters. In exemplary embodiments, vital sign parameters from a plurality of physiological systems are used to generate the forecast of the life-threatening condition. In exemplary embodiments, at least one vital sign parameter is other than a cardiac parameter. Non-limiting exemplary vital sign parameters may include one or more of a heart rate parameter, a respiration rate parameter, a bradycardia parameter, a desaturation parameter, a temperature parameter (for example, body temperature) and a body mass parameter.
