Aspects of the present invention relate to a multi-sensory manipulation system. The multi-sensory manipulation system is useable to train one or more senses through the manipulation of one or more sensory inputs as perceived by a user. The multi-sensory system may be used train a variety of senses, such as vision, hearing, olfactory, taste, touch, and the like. Consequently, the multi-sensory system may be comprised of a first sensory vitiation device that vitiates a sensory input for the first sense. The multi-sensory system may be comprised of a first sensory vitiation driver that generates vitiations instructions useable by the first sensory vitiation device. The multi-sensory system may also be comprised of a controller to coordinate one or more sensory drivers and/or one or more sensory vitiation devices to allow for the training of one or more senses through the manipulation of multiple sensory inputs.