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DERIVES DE CARBAZOLE, SES SOLVATES OU SES SELS PHARMACEUTIQUEMENT ACCEPTABLES
专利权人:
LTD.;ZERIA PHARMACEUTICAL CO.
发明人:
MURATA, MASAKAZU,ITOKAZU, YOSHIHIKO,NAKAO, RYU
申请号:
CA2585642
公开号:
CA2585642C
申请日:
2005.10.28
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
An object of the present invention is to provide novel carbazole derivatives,solvates thereof, or pharmaceutically acceptable salts thereof having anexcellentadipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemiceffect,which are useful as a preventive and/or therapeutic agent for fatty liver,obesity, lipidmetabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impairedglucosetolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholicsteatohepatitis, and the like.The above-mentioned object can be achieved by carbazole derivatives,solvates thereof, or pharmaceutically acceptable salts thereof, wherein thecarbazolederivatives are represented by the following general formula (I):(see formula I)(In the formula (I), the ring A represents phenyl group or the like; Xrepresents -O- orthe like; Y represents =N- or the like; a and b represent methylene group orthe like;both V and Z represent -O- or the like; W represents a C1-C10 alkylene groupwhose 1or 2 hydrogen atoms may be substituted by a phenyl group or a C1-C6 alkylgroup;1,2-phenylene group; 1,3-cyclohexyl group; or the like; R1 represents methylgroup orthe like; R2 represents methoxy group or the like; and R3 represents carboxygroup orthe like.)
来源网站:
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