The present disclosure relates to methods and devices for treatment of metabolic and/or gastrointestinal (GI) tract disorders and, more particularly, to surgical methods and devices for the treatment of type 2 diabetes mellitus and Barretts Esophagus. Even more particularly, the present disclosure pertains to methods and devices for disrupting or removing cells from the GI tract, and methods and devices for harvesting cells from one section of the GI tract and implanting those cells in another section of the GI tract.