PROBLEM TO BE SOLVED: To provide a method of evaluating a candidate substance for improving intestinal environment that can be performed simply and quickly and is highly accurate.SOLUTION: The method comprises at least the following steps A to E: a step A of applying a treatment that rises a redox potential in intestines to a non-human animal a step B of administering a test substance to the non-human animal a step C of measuring the redox potential of intestinal or extracorporeal feces of the non-human animal after the steps A and B a step D of comparing the redox potential value measured in the step C with a reference value and a step E of evaluating the test substance as a candidate substance for improving intestinal environment in the case where the comparison of the step D leads to the fact that the test substance suppresses the rise of the redox potential caused by the treatment of the step A.COPYRIGHT: (C)2014,JPO&INPIT【課題】簡便かつ迅速に実施することができ、精度の良い、腸内環境改善候補物質の評価方法を提供する。【解決手段】少なくとも以下の工程A~Eを有する。腸内の酸化還元電位を上昇させる処置を非ヒト動物に施す工程A、非ヒト動物に被験物質を投与する工程B、工程A及び工程Bより後に、非ヒト動物の腸内又は体外の糞便の酸化還元電位を測定する工程C、工程Cで測定した酸化還元電位の値を基準値と比較する工程D、工程Dにおける比較の結果、被験物質が工程Aにおける処置による酸化還元電位の上昇を抑制している場合に、被験物質を腸内環境改善候補物質と評価する工程E。【選択図】なし
