Yasuhiro Ikeda,Sara J. Holditch,Alessandro Cataliotti,Vicente E. Torres
申请号：
US15525344
公开号：
US20170333530A1
申请日:
2015.11.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This document provides methods and materials for using natriuretic polypeptides to reduce the generation of kidney cysts, to reduce the number of kidney cysts, to reduce the size of kidney cysts, and/or to reduce the weight of a mammals kidneys in mammals with polycystic kidney disease. For example, methods and materials for using natriuretic polypeptides (e.g., BNP) and/or nucleic acid encoding natriuretic polypeptides to reduce kidney cystogenesis and to reduce kidney organ to body weight ratios in mammals with mammals with polycystic kidney disease (e.g., autosomal recessive polycystic kidney disease) are provided.
