1-(3-(6,7-DIMETHOXYQUINAZOLIN-4-YLOXY)PHENYL)-3-(5-(1,1,1-TRIFLUORO-2-METHYLPROPAN-2-YL)ISOXAZOL-3-YL)UREA COMME MODULATEUR DE LA KINASE RAF POUR LE TRAITEMENT DES MALADIES DE CANCER

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专利权人:

AMBIT BIOSCIENCES CORPORATION

发明人:

申请号：

EP15166141.0

公开号：

EP2947072B1

申请日:

2009.03.17

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Compounds, compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. The compound is 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea, having the structure or a pharmaceutically acceptable salt, solvate, clathrate or hydrate thereof.

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