The present invention relates to a kind of prodrug or its pharmaceutically acceptable salts, include exendin peptide linker conjugate D-L, wherein D indicates exendin peptide moiety It is indicated with the formula (I) of the part-L1 abiology active links of head, wherein dotted line indicates that an amino for being connected to exendin peptide moiety forms amido bond. The invention further relates to the pharmaceutical composition for containing the prodrug and they as drug be used for treats or prevents can by Exendin treatment disease or illness.
