GRIMM, JAN,KAITTANIS, CHARALAMBOS,SHAFFER, TRAVIS M.
申请号：
CA2977101
公开号：
CA2977101A1
申请日:
2016.02.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Methods and compositions described herein use polysaccharide nanoparticles (or polysaccharide-coated nanoparticles) to retain and deliver unaltered therapeutic agents to sites of disease. The polysaccharide nanoparticles are non-covalently associated with the unaltered therapeutic agent. The polysaccharide is able to retain cargo (drugs, diagnostics, etc.) without chemical modification of the agent. The nanoparticle maintains its association with the agent through non-covalent interactions but releases its agent in response to changes in the microenvironment, e.g., at the site of cancer cells or cancer tissue.
